To investigate the dynamic parathyroid response to rapidly induced, sustained hypocalcaemia in patients with acute malaria and in healthy volunteers.
Serum intact parathormone (PTH) concentrations were measured on samples taken before and during a variable-rate tri-sodium citrate infusion designed to'clamp'the whole blood ionised calcium concentration 0.20 mmol L'below baseline for 120 min.
Six Malaysian patients aged 17-42 years with acute malaria, four of whom were restudied in convalescence, and 12 healthy controls aged 19-36 years.
Whole-blood ionised calcium and serum intact PTH concentrations.
The mean (SD baseline ionised calcium was lower in the malaria patients than in controls (1.09 ± 0.06 vs. 1.18 ± 0.03 mmol L-1, respectively : P=0.01) but PTH concentrations were similar (3.0 ± 1.8 vs. 3.3 ± 1.3 pmol L-1 ; P=0.33).
Target whole-blood ionised calcium concentrations were achieved more rapidly in the controls than the patients (within 15 vs. 30 min) despite significantly more citrate being required in the patients (area under the citrate infusion-time curve 0.95 (0.25 vs. 0.57 ± 0.09 mmol kg-1 ; P<0.01).
The ratio of the change in serum PTH to that in ionised calcium (deltaPTH/deltaCa2+), calculated to adjust for differences in initial rate of fall of ionised calcium, was similar during the first 5 min of the clamp (132 ± 75 X 10-6 vs. 131 43 x 10-6 in patients and controls, respectively.
Mots-clés Pascal : Paludisme, Protozoose, Parasitose, Infection, Aigu, Corrélation, Hypocalcémie, Parathormone, Etude comparative, Evaluation, Homme, Malaisie, Asie, Elément minéral, Trouble métabolisme, Trouble équilibre hydroélectrolytique
Mots-clés Pascal anglais : Malaria, Protozoal disease, Parasitosis, Infection, Acute, Correlation, Hypocalcemia, Parathormone, Comparative study, Evaluation, Human, Malaysia, Asia, Inorganic element, Metabolic disorder, Hydroelectrolytic balance disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0290085
Code Inist : 002B05E02B4. Création : 27/11/1998.