Occupational exposures, animal exposure and smoking as risk factors for hairy cell leukaemia evaluated in a case-control study.
To evaluate occupational exposures as risk factors for hairy cell leukaemia (HCL), a population-based case-control study on 121 male HCL patients and 484 controls matched for age and sex was conducted.
Elevated odds ratio (OR) was found for exposure to farm animals in general : OR 2.0,95% confidence interval (Cl) 1.2-3.2. The ORs were elevated for exposure to cattle, horse, hog, poultry and sheep.
Exposure to herbicides (OR 2.9, Cl 1.4-5.9), insecticides (OR 2.0, Cl 1.1-3.5), fungicides (OR 3.8, Cl 1.4-9.9) and impregnating agents (OR 2.4, Cl 1.3-4.6) also showed increased risk.
Certain findings suggested that recall bias may have affected the results for farm animals, herbicides and insecticides.
Exposure to organic solvents yielded elevated risk (OR 1.5, Cl 0.99-2.3), as did exposure to exhaust fumes (OR 2.1, Cl 1.3-3.3).
In an additional multivariate model, the ORs remained elevated for all these exposures with the exception of insecticides.
We found a reduced risk for smokers with OR 0.6 (Cl 0.4-1.1) because of an effect among non-farmers.
Mots-clés Pascal : Leucémie lymphohistiocytaire, Facteur risque, Epidémiologie, Exposition professionnelle, Animal élevage, Herbicide, Pesticide, Insecticide, Composé chimique, Toxicité, Tabagisme, Etude cas témoin, Suède, Europe, Registre, Homme, Chronique, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Hairy cell leukemia, Risk factor, Epidemiology, Occupational exposure, Farming animal, Herbicide, Pesticides, Insecticide, Chemical compound, Toxicity, Tobacco smoking, Case control study, Sweden, Europe, Register, Human, Chronic, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0289747
Code Inist : 002B19B. Création : 27/11/1998.