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  1. No association between a polymorphism in the steroid metabolism gene CYP17 and risk of breast cancer.

    Article - En anglais

    A recent study showed an association between a single base substitution, T

    The C allele was associated with increased risk of breast cancer, significantly so for patients presenting with advanced disease, whereas the TT genotype was associated with later age at menarche in control subjects.

    We attempted to confirm these findings in a large case-control study in East Anglia, England (835 cases and 591 control subjects).

    We found no evidence of an increased risk of breast cancer [odds ratio (OR) 1.10, confidence interval (Cl) 0.89-1.37] or advanced breast cancer (OR 0.88, Cl 0.38-2.01) in C allele carriers, nor any association between age at menarche and genotype.

    We conclude that these alleles do not significantly alter breast cancer risk in the English population.

    Mots-clés Pascal : Tumeur maligne, Glande mammaire, Métabolisme, Hormone stéroïde sexuelle, Polymorphisme, Gène, Variabilité génétique, Cytochrome P450, Facteur risque, Epidémiologie, Angleterre, Grande Bretagne, Royaume Uni, Europe, Etude cas témoin, Homme, Glande mammaire pathologie, Gène CYP17

    Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Metabolism, Sex steroid hormone, Polymorphism, Gene, Genetic variability, Cytochrome P450, Risk factor, Epidemiology, England, Great Britain, United Kingdom, Europe, Case control study, Human, Mammary gland diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0289746

    Code Inist : 002B20E02. Création : 27/11/1998.