Several studies have found that coffee consumption is related to a lower risk of colorectal cancer, but results have not been consistent.
Thus, a meta-analysis of the published articles was conducted to examine this relation.
Because of the various ways data were collected and analyzed, a « semiquantitative » approach that compared the high versus the low category of intake for each study was used.
The combined results from 12 case-control studies showed an inverse association between coffee consumption and risk of colorectal cancer (pooled relative risk (estimated by odds ratio) for high vs. low category of coffee consumption (RR)=0.72,95% confidence interval (Cl) 0.61-0.84) ; the findings were similar in population-based and hospital-based case-control studies.
Five cohort studies did not support an association (pooled RR=0.97,95% Cl 0.73-1.29).
The combined results of all studies were driven largely by the case-control studies, which comprised 85 percent of the cases (RR=0.76,95% Cl 0.66-0.89).
The lower risk of colorectal cancer among substantial coffee drinkers was observed in studies from Asia, Northern and Southern Europe, and North America. (...)
Mots-clés Pascal : Tumeur maligne, Côlon, Rectum, Café, Caféine, Consommation, Epidémiologie, Facteur risque, Homme, Métaanalyse, Etude cas témoin, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Alimentation
Mots-clés Pascal anglais : Malignant tumor, Colon, Rectum, Coffee, Caffeine, Consumption, Epidemiology, Risk factor, Human, Metaanalysis, Case control study, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Feeding
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0289383
Code Inist : 002B13B01. Création : 27/11/1998.