Among 2,496 infertile Israeli women treated between 1964 and 1974,143 cancer cases were observed as compared with 116.1 expected (standardized incidence ratio (SIR)=1.2,95% confidence interval (Cl) 1.0-1.5) through 1991.
Site-specific analysis revealed 12 ovarian cancers versus 7.2 expected (SIR=1.6,95% Cl 0.8-2.9), 21 endometrial cancers versus 4.3 expected (SIR=4.85,95% Cl 3.0-7.4), and 59 breast cancers versus 46.6 expected (SIR=1.3,95% Cl 0.96-1.6).
Sensitivity analysis revealed that confounding was unlikely to explain the raised risk of endometrial cancer, but nulliparity might explain the increased risk of ovarian cancer.
The excess of endometrial cancer was prominent among patients with normal estrogen production but progesterone deficiency (SIR=9.4,95% Cl 5.0-16.0).
The risk for ovarian cancer was similar among the total groups of treated and untreated patients (SIR=1.7 vs. 1.6).
The standardized incidence ratio for endometrial cancer was higher among the treated group than the untreated group, although not significantly.
Treatment with ovulation-inducing drugs does not appear to increase the risk for ovarian cancer, but its role cannot be completely excluded.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Ovaire, Endomètre, Stérilité femelle, Inducteur ovulation, Médicament, Epidémiologie, Incidence, Facteur risque, Homme, Femelle, Etude cohorte, Toxicité, Glande mammaire pathologie, Ovaire pathologie, Utérus pathologie, Appareil génital femelle pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Ovary, Endometrium, Female sterility, Ovulation inducer, Drug, Epidemiology, Incidence, Risk factor, Human, Female, Cohort study, Toxicity, Mammary gland diseases, Ovarian diseases, Uterine diseases, Female genital diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0289379
Code Inist : 002B20C02. Création : 27/11/1998.