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  1. Celiac disease risk in the USA : High prevalence of antiendomysium antibodies in healthy blood donors.

    Article - En anglais

    Background 

    Recent epidemiologic studies in Europe using antigliadin (AGA) and antiendomysium antibodies (AEA) for initial screening have shown that the overall prevalence of celiac disease (CD) is about 1 : 300.

    There are no comparable scientific data for the USA, where CD is considered rare.

    The main aim of this study was to determine the prevalence of increased AEA in healthy blood donors in the USA.

    Methods 

    Sera from 2000 healthy blood donors were screened for IgG AGA and IgA AGA with an enzyme-linked immunosorbent assay test.

    All those with increased AGA levels, those with intermediate levels, and random samples with low levels were tested for AEA, using both monkey esophagus (ME) and human umbilical cord (HUC) cryosections as substrates.

    Results 

    The mean age of the blood donors was 39 years, with 52% being men, 85.2% being Caucasian, 11.8% African-American, 1.5% Asian, and 1.5% Hispanic.

    Eight healthy blood donors had positive AEA tests on both monkey esophagus and human umbilical cord.

    Among the eight subjects with increased AEA levels seven were Caucasian and one was African-American-All the four examined AEA-positive donors carried the known susceptibility alleles for CD.

    Conclusions 

    The prevalence of increased AEA levels in healthy blood donors in the USA is 1 : 250 (8 : 2000).

    This is similar to that reported in countries in Europe, where subsequent small-intestinal biopsies have confirmed CD in all those with AEA positivity. (...)

    Mots-clés Pascal : Coeliaque maladie, Prévalence, Diagnostic, Anticorps, Spécificité, Gliadine, Dépistage, Donneur sang, Facteur risque, Origine ethnique, Déterminisme génétique, Epidémiologie, Homme, Etats Unis, Amérique du Nord, Amérique, Appareil digestif pathologie, Intestin pathologie, Malabsorption intestinale, Immunopathologie, Endomysium

    Mots-clés Pascal anglais : Coeliac disease, Prevalence, Diagnosis, Antibody, Specificity, Gliadin, Medical screening, Blood donor, Risk factor, Ethnic origin, Genetic determinism, Epidemiology, Human, United States, North America, America, Digestive diseases, Intestinal disease, Intestinal malabsorption, Immunopathology, Endomysium

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0287778

    Code Inist : 002B30A01A2. Création : 27/11/1998.