Pharmacoeconomic evaluation of high-dose chemotherapy and peripheral blood stem cell support in high-risk or poor-prognosis malignancies.
Discussion of the total costs and cost-effectiveness ratios of patients receiving high-dose chemotherapy (HDC) and peripheral blood stem cell support (PBSCS) is controversial.
In Germany, no reliable data are available, whereas in other countries this issue has been extensively studied.
We performed a pharmacoeconomic evaluation on all patients (n=37) treated with HDC and PBSCS at our institution between July 1994 and June 1997.
Patients suffered from high-risk or poor-prognosis breast cancer (n=24), Hodgkin's disease (n=3), high-grade non-Hodgkin's lymphoma (n=4), multiple myeloma (n=2), small-cell cervical cancer (n=1), malignant hystiocytosis (n=1) and testicular cancer (n=2).
For pharmacoeconomic evaluation, the period from initiation of induction chemotherapy (IC) until reconstitution after the last course of HDC and PBSCS was considered.
A total of 18 patients received IC/HDC/PBSCS for locally advanced or systemic disease, and 19 patients received adjuvant or consolidation IC/HDC/PBSCS.
Treatment protocols were heterogeneous.
Patients were treated with two to five courses (median two) respectively of IC and sequential mono-HDC (n=26), tandem-HDC (n=10) or triple-HDC (n=1).
All patients received granulocyte/macrophage-colony-stimulating factor (G-CSF) for stem cell mobilisation and for amelioration of neutropenia after HDC.
The relative costs (based on supplier prices) for the total amount of drugs prescribed during the in-patient period was 29.8% for G-CSF, 35. (...)
Mots-clés Pascal : Tumeur maligne, Traitement, Chimiothérapie, Anticancéreux, Dose forte, Cellule souche, Cellule hématopoïétique, Traitement associé, Antibiotique, Coût, Analyse coût efficacité, Homme, Economie santé
Mots-clés Pascal anglais : Malignant tumor, Treatment, Chemotherapy, Antineoplastic agent, High dose, Stem cell, Hematopoietic cell, Combined treatment, Antibiotic, Costs, Cost efficiency analysis, Human, Health economy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0285920
Code Inist : 002B02R02. Création : 27/11/1998.