Adverse lipid and coronary heart disease risk profiles in young women with polycystic ovary syndrome : Results of a case-control study.
Polycystic ovary syndrome (PCOS), a disorder of hyperandrogenism and chronic anovulation affects 5% - 10% of all women.
Women with PCOS often have elevated cardiovascular risk factors.
A total of 244 PCOS cases were identified through the Division of Reproductive Endocrinology at Magee-Womens Hospital and were age-matched to 244 neighborhood controls.
The average age of cases and controls was 35.3 ± 7.4 and 36.7 ± 7.7. Women with PCOS compared to controls had substantially higher LDL-C and total cholesterol levels at each age group under 45 years after adjustment for body mass index, hormone use, and insulin levels.
In the over 40-year age group, little difference was noted between cases and controls.
Among cases and controls (<40), PCOS predicted LDL-C, total cholesterol and triglycerides, but did not have a significant effect on lipid levels in older cases and controls after controlling for the other variables.
The primarily pre-to perimenopausal PCOS cases =40 years of age have similar LDL-C and total cholesterol levels as their age-matched controls, probably reflecting the LDL-C increase with age among controls.
Mots-clés Pascal : Cardiopathie coronaire, Hyperlipémie, Ovaire polykystique, Epidémiologie, Facteur risque, Femme, Homme, Adulte jeune, Etats Unis, Amérique du Nord, Amérique, Lipide, Etude cas témoin, Appareil circulatoire pathologie, Métabolisme pathologie, Dyslipémie, Appareil génital femelle pathologie, Ovaire pathologie, Stérilité femelle, Tumeur bénigne, Kyste
Mots-clés Pascal anglais : Coronary heart disease, Hyperlipemia, Polycystic ovary, Epidemiology, Risk factor, Woman, Human, Young adult, United States, North America, America, Lipids, Case control study, Cardiovascular disease, Metabolic diseases, Dyslipemia, Female genital diseases, Ovarian diseases, Female sterility, Benign neoplasm, Cyst
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0281675
Code Inist : 002B12A03. Création : 27/11/1998.