Despite widespread vaccination during 30 years, the hypothesis of a resurgence of pertussis in France has been raised by outbreaks and sporadic case reports.
A survey was undertaken in 1993 and 1994 in a pediatric hospital network able to confirm cases ; the network (22 hospitals) represents 19.6% of pediatric admissions in France.
Case definition included clinical (=21 days of paroxysmal cough), laboratory-confirmed (culture or serology by immunoblot) or epidemiologically confirmed pertussis (documented contact with a laboratory-confirmed case).
The pattern of transmission was studied in the household.
Vaccine status was obtained from health records.
During a 15-month period 560 cases (316 index cases, 244 household contact cases) were reported ; 49% of index cases and 20% of contact cases were confirmed by culture and/or serology.
Sixty-five percent of index cases were younger than 1 year of age (the incidence in this age group could be estimated to be 95/100 000) and 66% were hospitalized for a mean duration of 2 weeks.
Infection was acquired from parents (34%) and siblings (46%). Seventy-three percent of index cases were unvaccinated.
Although pertussis vaccination coverage is very high in France, the organism is still circulating, affecting, within the pediatric population, mostly non-or incompletely vaccinated infants. (...)
Mots-clés Pascal : Coqueluche, Bactériose, Infection, Bordetella pertussis, Bactérie, Immunoprophylaxie, Prévention, Vaccination, Epidémiologie, Enfant, Homme, France, Europe, Transmission homme homme, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Whooping cough, Bacteriosis, Infection, Bordetella pertussis, Bacteria, Immunoprophylaxis, Prevention, Vaccination, Epidemiology, Child, Human, France, Europe, Transmission from man to man, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0275644
Code Inist : 002B05B02E. Création : 27/11/1998.