High frequency of iron bone deposits in a Mexican population with renal osteodystrophy.
Advances in Renal Osteodystrophy. International Symposium. Oviedo, ESP, 1997/03/20.
Renal osteodystrophy (ROD) is a multifactorial disease.
Aluminium deposits have been implicated in its physiopathology but iron deposits have seldom been described.
The purpose of this study was to investigate the presence of iron on the mineralization front, in 70 patients with ROD.
Their mean age was 48 ± 16 years, 36 were female, 34 male, 55 were admitted on peritoneal dialysis (78.5%) and 15 to haemodialysis (21.5%), for a period of 28 ± 22 months.
A bone biopsy was obtained from each patient after double tetracycline labelling.
Blood samples were also obtained at the time of bone biopsy.
The histomophometric analysis was performed following the criteria of Sherrard et al., with slight modifications ; beside the usual stains, aluminium, iron and amyloid stainings were done on all bone specimens.
Biochemical findings were :
Ca 8.8 ± 0.9 mg/dl, P 6.1 ± 1.5 mg/dl ; total alkaline phosphatase 197 ± 258 ; PTHm 4.9 ± 4.05 ng/ml (normal 0.4-0.7 ng/ml), calcitonin 11 ± 6 pg/ml (normal 1-26 pg/ml).
Osteitis fibrosa was found in 31 patients (44.28%), mixed bone disease in two patients (2.28%) ; mild bone disease in 20 subjects (28.57%), adynamic bone lesion in 15 cases (21.42%) and osteomalacia in two patients (2.28%). Iron deposits were found on the mineralization front in 43 patients (61.4%) ; in 17, the percentage was<25 and, in 26,>25%. The iron deposits in the osteitis fibrosa group were highly significant (25/31). (...)
Mots-clés Pascal : Ostéodystrophie rénale, Pathogénie, Effet biologique, Dépôt fer, Os, Front, Minéralisation, Morphométrie, Ostéoblaste, Incidence, Epidémiologie, Homme, Mexique, Amérique Centrale, Amérique, Système ostéoarticulaire pathologie, Appareil urinaire pathologie, Rein pathologie, Métabolisme pathologie, Histopathologie
Mots-clés Pascal anglais : Renal osteodystrophy, Pathogenesis, Biological effect, Iron coating, Bone, Forehead, Mineralization, Morphometry, Osteoblast, Incidence, Epidemiology, Human, Mexico, Central America, America, Diseases of the osteoarticular system, Urinary system disease, Kidney disease, Metabolic diseases, Histopathology
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0275486
Code Inist : 002B15I. Création : 27/11/1998.