Isocyanates are some of the most important low molecular weight chemicals associated with occupational asthma.
These compounds are often volatile and they are highly reactive on mucous membranes, especially the conjunctivae and respiratory tract.
Despite numerous data derived from experimental and clinical investigations, there is no agreement concerning the real mechanisms involved in isocyanate-induced occupational asthma.
In fact, the cause of occupational asthma is multifactorial.
The aim of this paper is to review the involved physiological causes of isocyanate-induced asthma ; the main mechanisms are immunological, pharmacological and/or irritative.
Mots-clés Pascal : Isocyanate organique, Toxicité, Exposition professionnelle, Médecine travail, Homme, Asthme, Mécanisme action, Pathogénie, Irritation, Allergie, Récepteur adrénergique, Appareil respiratoire pathologie, Bronchopneumopathie obstructive
Mots-clés Pascal anglais : Organic isocyanate, Toxicity, Occupational exposure, Occupational medicine, Human, Asthma, Mechanism of action, Pathogenesis, Irritation, Allergy, Adrenergic receptor, Respiratory disease, Obstructive pulmonary disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0274669
Code Inist : 002B11B. Création : 27/11/1998.