A large cohort of men born between 1891 and 1920 and employed for at least a month in the chrysotile producing industry of Quebec has been under study since 1966.
These men were followed from first employment (the earliest in 1904) to 1992, by which time over 8000 had died, 657 from lung cancer.
The current study is of 488 cases of lung cancer formerly employed at three places, viz. a major complex, here called Company 3, in the region of Thetford Mines (243 cases), the mine and mill in the town of Asbestos (206) and a small asbestos-products factory in the same town (39).
For each case, four referents were sought by random selection from among survivors to a greater age, after matching on place of employment, age of starting work, smoking habit and date of birth.
This process was highly successful, although six cases had less than four referents.
For each man (the 488 cases with 1941 referents) and for each calendar year of employment, we obtained the fraction of the year worked at various levels of intensity, assessed in 13'dust categories'of mpcf (million particles per cubic foot).
We then calculated how many years each man spent at these various levels ; these years, adjusted for the length of the working week (66h until 1937 ; 48h 1938-1949 ; and 40h 1950-1985), were accumulated up to ten years before the death of the case.
The men were classified according as they were non-or ex-smokers, or smokers, of cigarettes. (...)
Mots-clés Pascal : Poussière, Toxicité, Exposition professionnelle, Médecine travail, Homme, Tumeur maligne, Bronchopulmonaire, Epidémiologie, Amiante, Chrysotile, Québec, Canada, Amérique du Nord, Amérique, Industrie extractive, Mine, Mortalité, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Dust, Toxicity, Occupational exposure, Occupational medicine, Human, Malignant tumor, Bronchopulmonary, Epidemiology, Asbestos, Quebec, Canada, North America, America, Mining industry, Mine, Mortality, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0274316
Code Inist : 002B03L03. Création : 27/11/1998.