Annual Meeting of the Society for Epidemiologic Research. Edmonton, AB, CAN, 1997/06/12.
Established breast cancer risk factors, in addition to being relatively unmodifiable, are highly prevalent among US women.
Previous reports of population attributable fraction for the established risk factors have used definitions that resulted in 75-100% of women in the source population labeled exposed.
The practical value of such estimates has not been discussed ; further, the estimates have frequently been misinterpreted.
In the context of examining the interpretation and public health value of such estimates, the authors demonstrate the sensitivity of the population attributable fraction to changes in exposure cutpoints.
They use data from the Carolina Breast Cancer Study, a case-control study of breast cancer conducted in North Carolina between 1993 and 1996.
For the four established risk factors (menarche before age 14 years, first birth at age 20 years or later/nulliparity, family history of breast cancer, and history of benign breast biopsy), the estimated population attributable fraction was 0.25 (95% confidence interval 0.06-0.48).
Over 98% of the source population was exposed to at least one of these risk factors.
The population attributable fraction estimate was reduced to 0.15 when more restrictive definitions of early menarche (less than age 12 years) and late age at first full-term pregnancy (30 years or more) were used (proportion exposed, 0.62). (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Epidémiologie, Facteur risque, Homme, Femelle, Etats Unis, Amérique du Nord, Amérique, Etude cas témoin, Glande mammaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Epidemiology, Risk factor, Human, Female, United States, North America, America, Case control study, Mammary gland diseases
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0272651
Code Inist : 002B20E02. Création : 27/11/1998.