The authors investigated risk profiles of sudden infant death syndrome (SIDS) as a function of age at death.
A case-control study carried out in the Tyrol region of Austria enrolled 99 infants who died of SIDS between 1984 and 1994 and 136 randomly selected controls.
Early and late SIDS (<120 days of age vs. = 20 days) were defined according to the clear-cut bimodal age-at-death distribution.
Inadequate antenatal care, low parental social and educational level, and the prone sleeping position were risk conditions that applied to both early and late SIDS.
A marked seasonal variation (winter preponderance) was the most outstanding feature of late SIDS.
A gestational age of<37 weeks (odds ratio (OR)=8.4,95% confidence interval (Cl) 2.6-26.0), repeated episodes of apnea (OR=5.7,95% CI 1.2-27.0), low birth weight (<2,500 g) (OR=3.4,95% Cl 1.1-11.0), a family history of sudden infant death (OR=2.9,95% Cl 1.1-7.5), and maternal smoking during pregnancy (OR=2.2,95% Cl 1.0-4.5) were associated with early SIDS.
This study identified two distinct subgroups of SIDS infants characterized by different risk conditions and ages at death.
These results underline a multiple-cause hypothesis for SIDS etiology which involves a genetic predisposition, immaturity in the first months of life, and environmental factors acting at various ages.
Mots-clés Pascal : Mort subite, Mortalité, Postnatal, Epidémiologie, Facteur risque, Nourrisson, Homme, Autriche, Europe
Mots-clés Pascal anglais : Sudden death, Mortality, Postnatal, Epidemiology, Risk factor, Infant, Human, Austria, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0272579
Code Inist : 002B30A01A1. Création : 27/11/1998.