The authors present a nonparametric method for estimating vaccine efficacy as a smooth function of time from vaccine trials.
Use of the method requires a minimum of assumptions.
Estimation is based on the smoothed case hazard rate ratio comparing the vaccinated with the unvaccinated.
The estimation procedure allows investigators to assess time-varying changes in vaccine-induced protection, such as those produced by waning and boosting.
The authors use the method to reanalyze data from a vaccine trial of two cholera vaccines in rural Bangladesh.
This analysis reveals the differential protection and waning effects for the vaccines as a function of biotype and age.
Mots-clés Pascal : Vaccination, Choléra, Bactériose, Infection, Estimation non paramétrique, Analyse statistique, Etude en condition contrôlée, Evaluation, Efficacité, Méthodologie, Homme, Etude comparative, Bengla Desh, Asie, Prévention
Mots-clés Pascal anglais : Vaccination, Cholera, Bacteriosis, Infection, Non parametric estimation, Statistical analysis, Controlled environment study, Evaluation, Efficiency, Methodology, Human, Comparative study, Bangladesh, Asia, Prevention
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0272574
Code Inist : 002B30A01A1. Création : 27/11/1998.