logo BDSP

Base documentaire

  1. Fulltext. Estimation of vaccine efficacy in the presence of waning : Application to cholera vaccines.

    Article - En anglais


    The authors present a nonparametric method for estimating vaccine efficacy as a smooth function of time from vaccine trials.

    Use of the method requires a minimum of assumptions.

    Estimation is based on the smoothed case hazard rate ratio comparing the vaccinated with the unvaccinated.

    The estimation procedure allows investigators to assess time-varying changes in vaccine-induced protection, such as those produced by waning and boosting.

    The authors use the method to reanalyze data from a vaccine trial of two cholera vaccines in rural Bangladesh.

    This analysis reveals the differential protection and waning effects for the vaccines as a function of biotype and age.

    Mots-clés Pascal : Vaccination, Choléra, Bactériose, Infection, Estimation non paramétrique, Analyse statistique, Etude en condition contrôlée, Evaluation, Efficacité, Méthodologie, Homme, Etude comparative, Bengla Desh, Asie, Prévention

    Mots-clés Pascal anglais : Vaccination, Cholera, Bacteriosis, Infection, Non parametric estimation, Statistical analysis, Controlled environment study, Evaluation, Efficiency, Methodology, Human, Comparative study, Bangladesh, Asia, Prevention

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0272574

    Code Inist : 002B30A01A1. Création : 27/11/1998.