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  1. Factor V Leiden is not a risk factor for arterial vascular disease in the elderly : Results from the Cardiovascular Health Study.

    Article - En anglais

    Coagulation factor V Leiden is a risk marker for venous thrombosis.

    For arterial thrombosis no large study to date has included population-based elderly patients.

    The Cardiovascular Health Study is a longitudinal study of 5.201 men and women over age 65.

    With 3.4-year follow-up. we studied 373 incident cases of myocardial infarction (MI). angina, stroke, or transient ischemic attack (TIA), and 482 controls.

    The odds ratios for each event with heterozygous factor V Leiden were : MI. 0.46 (95% Cl 0.17 to 1.25) : angina, 1.0 (95% CI 0.45 to 2.231 ; stroke. 0.77 (95% Cl 0.35 to 1.70) : TIA, 1.33 (95% Cl 0.5 to 3.55) : any outcome. 0.83 (95% Cl 0.48 to 1.44).

    Adjustment for cardiovascular risk factors did not change relationships.

    In older adults factor V Leiden is not a risk factor for future arterial thrombosis.

    Mots-clés Pascal : Thrombose, Artère, Facteur risque, Epidémiologie, Facteur V Leiden, Etude cas témoin, Etats Unis, Amérique du Nord, Amérique, Vieillard, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Artère pathologie

    Mots-clés Pascal anglais : Thrombosis, Artery, Risk factor, Epidemiology, Factor V Leiden, Case control study, United States, North America, America, Elderly, Human, Cardiovascular disease, Vascular disease, Arterial disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0271593

    Code Inist : 002B12B03. Création : 27/11/1998.