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  1. Fulltext. Natural course of schizophrenic disorders : A 15-year followup of a dutch incidence cohort.

    Article - En anglais


    Data are presented on the 15-year natural course of schizophrenia and other nonaffective functional psychoses in a cohort of 82 first-contact cases from a circumscribed area in the Netherlands.

    The subjects were suffering from functional psychosis with International Classification of Diseases-Ninth Revision (ICD-9) diagnoses 295,297, or 298.3-9 (broad definition of schizophrenia) on entry.

    Standardized assessments of psychopathology, psychological impairments, negative symptomatology, social disability, and use of mental healthcare were used.

    The study reveals a pattern of chronicity and relapses with a high risk of suicide :

    • Two-thirds of the subjects had at least one relapse and after each relapse 1 of 6 subjects did not remit from the episode ;

    • 1 of 10 committed suicide ;

    • and 1 of 7 had at least one episode with affective psychotic symptoms that started on average 6 years after the onset of the schizophrenic disorder.

    Diagnoses were reclassified in five patients, according to DSM-III-R criteria for a bipolar disorder.

    The predictive power-in terms of time in psychosis and in partial or full remission-of demographic, illness, and treatment variables at onset of the illness was very limited.

    Insidious onset and delays in mental health treatment are risk factors that predict a longer duration of first or subsequent episodes. (...)

    Mots-clés Pascal : Schizophrénie, Evolution, Etude longitudinale, Long terme, Etude cohorte, Pays Bas, Europe, Epidémiologie, Chronicité, Récidive, Santé mentale, Homme, Psychose

    Mots-clés Pascal anglais : Schizophrenia, Evolution, Follow up study, Long term, Cohort study, Netherlands, Europe, Epidemiology, Chronicity, Relapse, Mental health, Human, Psychosis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0271311

    Code Inist : 002B18C06A. Création : 27/11/1998.