The lung concentration of angular and fibrous particles was measured in cases of lung fibrosis only, in cases of lung fibrosis and lung cancer, and in cases of lung cancer only.
These patients worked in different trades (mining, foundries, construction and were not a homogeneous group of exposed workers.
Particles, both angular and fibrous, were extracted from lung parenchyma by a bleach digestion method, mounted on copper microscopic grids by a carbon replica technique, and analyzed by transmission electron microscopy (TEM) and energy-dispersive spectroscopy (EDS).
The quartz concentration was also determined by X-ray diffraction (XRD) on a silver membrane filter after extraction from the lung parenchyma.
(1) Lung cancer and lung fibrosis cases retained more metal-rich particles (P=0.02) and more angular particles of all sorts (P=0.009) than did lung fibrosis cases only, and the differences were statistically significant. (2) However, more quartz was retained in the lungs in lung fibrosis cases than in lung fibrosis or lung cancer cases, but the difference in the concentrations was not statistically significant. (3) More ferruginous bodies were retained in the lungs in lung cancer and lung fibrosis cases than in cases of lung fibrosis only, and the difference in the concentrations was statistically significant (P=0.02).
Results obtained from lung tissue must always be interpreted cautiously. (...)
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Pneumopathie interstitielle, Fibrose, Toxicité, Exposition professionnelle, Silice, Analyse quantitative, Poumon, Poussière, Microscopie électronique transmission, Dispersion énergie, Spectrométrie, Fibre minérale, Forme particule, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Taux, Homme, Médecine travail
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Interstitial pneumonitis, Fibrosis, Toxicity, Occupational exposure, Silica, Quantitative analysis, Lung, Dust, Transmission electron microscopy, Energy dispersion, Spectrometry, Mineral fiber, Particle shape, Respiratory disease, Lung disease, Bronchus disease, Rate, Human, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0269534
Code Inist : 002B11A. Création : 27/11/1998.