This study investigated whether differences in the prevalence and severity of coal workers'pneumoconiosis (CWP) between three coal mines could be related to differences in oxidative stress exposure as evaluated in vivo through red-blood-cell antioxidant enzyme activities.
Blood samples were obtained from 229 miners selected according to their occupation and their pneumoconiotic status.
The following biomarkers were evaluated : erythrocyte catalase, Cu2+/Zn2+superoxide dismutase (Cu2+/Zn2+SOD), and glutathione peroxidase activities.
Antioxidant enzyme activities did not differ significantly between the group of surface workers in Lorraine and the group of underground miners without CWP in Lorraine and in the other coal mines.
Erythrocyte Cu2+/Zn2+SOD activity was slightly decreased in the group of active underground miners with simple pneumoconiosis as compared with the group of miners without CWP in Nord/Pas-de-Calais.
No effect was seen between retired miners at different stages of CWP.
Our findings indicate that differences in the prevalence and severity of CWP do not seem to be related to various oxidative activities of coal dust particles, at least as reflected by measurements of antioxidant enzyme activities in circulating erythrocytes in this study.
Mots-clés Pascal : Pneumoconiose, Mine charbon, Exposition professionnelle, Stress oxydatif, Antioxydant, Erythrocyte, Enzyme, Marqueur biologique, Poussière, Homme, France, Europe, Médecine travail, Appareil respiratoire pathologie, Poumon pathologie
Mots-clés Pascal anglais : Pneumoconiosis, Coal mine, Occupational exposure, Oxidative stress, Antioxidant, Red blood cell, Enzyme, Biological marker, Dust, Human, France, Europe, Occupational medicine, Respiratory disease, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0269533
Code Inist : 002B03L03. Création : 27/11/1998.