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  1. Hepatitis C virus infection in non-Hodgkin's lymphoma.

    Article - En anglais

    Hepatitis C virus (HCV) infection is associated with immune-complex mediatcd disorders, including type II mixed cryoglobulinaemia.

    Mixed cryoglobulinaemia is itself low-grade 13-cell lymphoproliferative disorder which may progress to non-Hodgkin's lymphoma (NHL).

    Studies from Europe and Asia have found a prevalence of hepatitis C virus infection in non-liodgkin's lymphoma patients as high as 34%. 0ther viral infections are also associated with non-Hodgkin's lymphoma.

    We speculated that non-Hodgkin's lymphoma patients in the midwestern USA would have an increased prevalence of hepatitis C infection.

    We tested 73 patients with NHL and 20 controls with Hodgkin's disease for anti-HCV antibodies by EIA-2.

    Only 1/73 patients and no control subject was positive for anti-HCV.

    The anti-HCV positive patient had no identifiable risk factors for hepatitis C, and Al/r was persistently normal.

    HCV-RNA testing by RT-PCR was negative.

    Thus, none of 73 non-Hodgkin's lymphoma patients could be confirmed to have hepatitis C infection.

    In a second part of the study. of 41 patients with HCV infcction followed an average of 28.1 months, only one patient developed non-Hodgkin's lymphoma.

    We conclude that in our population, non-Hodgkin's lymphoma is not associated with hepatitis C virus infection.

    Based on these results and review of the literature, there are marked regional differences in the prevalence of hepatitis C infection in Non-Hodgkin's lymphoma.

    Mots-clés Pascal : Hépatite virale C, Virose, Infection, Lymphome non hodgkinien, Etiologie, Variation géographique, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Homme, Appareil digestif pathologie, Foie pathologie, Hémopathie maligne, Lymphoprolifératif syndrome

    Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Non Hodgkin lymphoma, Etiology, Geographical variation, Epidemiology, United States, North America, America, Human, Digestive diseases, Hepatic disease, Malignant hemopathy, Lymphoproliferative syndrome

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0268071

    Code Inist : 002B19B. Création : 11/09/1998.