Hepatitis C virus infection in non-Hodgkin's lymphoma.
Hepatitis C virus (HCV) infection is associated with immune-complex mediatcd disorders, including type II mixed cryoglobulinaemia.
Mixed cryoglobulinaemia is itself low-grade 13-cell lymphoproliferative disorder which may progress to non-Hodgkin's lymphoma (NHL).
Studies from Europe and Asia have found a prevalence of hepatitis C virus infection in non-liodgkin's lymphoma patients as high as 34%. 0ther viral infections are also associated with non-Hodgkin's lymphoma.
We speculated that non-Hodgkin's lymphoma patients in the midwestern USA would have an increased prevalence of hepatitis C infection.
We tested 73 patients with NHL and 20 controls with Hodgkin's disease for anti-HCV antibodies by EIA-2.
Only 1/73 patients and no control subject was positive for anti-HCV.
The anti-HCV positive patient had no identifiable risk factors for hepatitis C, and Al/r was persistently normal.
HCV-RNA testing by RT-PCR was negative.
Thus, none of 73 non-Hodgkin's lymphoma patients could be confirmed to have hepatitis C infection.
In a second part of the study. of 41 patients with HCV infcction followed an average of 28.1 months, only one patient developed non-Hodgkin's lymphoma.
We conclude that in our population, non-Hodgkin's lymphoma is not associated with hepatitis C virus infection.
Based on these results and review of the literature, there are marked regional differences in the prevalence of hepatitis C infection in Non-Hodgkin's lymphoma.
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Lymphome non hodgkinien, Etiologie, Variation géographique, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Homme, Appareil digestif pathologie, Foie pathologie, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Non Hodgkin lymphoma, Etiology, Geographical variation, Epidemiology, United States, North America, America, Human, Digestive diseases, Hepatic disease, Malignant hemopathy, Lymphoproliferative syndrome
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0268071
Code Inist : 002B19B. Création : 11/09/1998.