Reduced incidence of septic arthritis in children by Haemophilus influenzae type-b vaccination : Implications for treatment.
In many countries Haemophilus influenzae type b (Hib) is the second most common cause of septic arthritis in children.
In Finland large-scale immunisation against Hib using conjugate vaccines began in 1986, four years after a multicentre prospective study of orthopaedic infections in children had started.
Since 1982, including six years before and ten after starting routine Hib vaccination, there has been a major change in the pattern of septic arthritis.
From 1982 to 1988,32 of 61 cases (53%) were caused by staphylococci, 22 (36%) by Hib and 7 (11%) by other bacteria.
Since 1988, Hib infection has disappeared, and one-third of cases of childhood septic arthritis has been eliminated.
This change has allowed us to reduce initial antimicrobial therapy for such children to cover only Gram-positive cocci.
The more limited treatment is safer, reduces cost, and simplifies treatment.
Mots-clés Pascal : Arthrite, Articulation, Infection, Haemophilus influenzae, Pasteurellaceae, Bactérie, Prévention, Vaccination, Immunoprophylaxie, Traitement, Efficacité traitement, Epidémiologie, Finlande, Europe, Incidence, Nourrisson, Homme, Enfant, Système ostéoarticulaire pathologie, Arthropathie, Bactériose
Mots-clés Pascal anglais : Arthritis, Joint, Infection, Haemophilus influenzae, Pasteurellaceae, Bacteria, Prevention, Vaccination, Immunoprophylaxis, Treatment, Treatment efficiency, Epidemiology, Finland, Europe, Incidence, Infant, Human, Child, Diseases of the osteoarticular system, Arthropathy, Bacteriosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0267298
Code Inist : 002B05B02J. Création : 11/09/1998.