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  1. Dissolution of gallbladder stones with methyl tert-butyl ether and stone recurrence : a European survey.

    Article - En anglais

    Since there are now several ways to treat symptomatic gallstone disease, one is able to select treatment on the basis of the patient's comfort, the practicability, effectiveness, and side effects of the technique, and the relative costs.

    In order to assess the present status of contact dissolution with methyl tert-butyl ether with regard to these aspects, the present enquiry reports the data of 21 European hospitals.

    Eight hundred three patients were selected for contact litholysis of cholesterol gallbladder stones using methyl tert-butyl ether.

    Percutaneous transhepatic puncture of the gallbladder was performed under x-ray or ultrasound guidance.

    Dissolution rate, side effects, and treatment times of 268 patients from one single center were compared to those of 535 patients from the other 20 centers.

    Two hundred sixty-four patients were followed for five years to assess stone recurrence.

    Physicians were asked how they assessed the expenditure of the method, the discomfort to the patients, and the staffing situation.

    Patients were asked to indicate their acceptance on an analog scale.

    Puncture was successful in 761 (94.8%) patients

    Prophylactic administration of antibiotics was not necessary.

    Stones were dissolved in 724 (95.1%) patients

    In 315 (43.5%) sludge remained in the gallbladder.

    The most severe complication was bile leakage, which led 12 (1.6%) patients to have elective cholecystectomy.

    Toxic injuries due to the ether were not reported. (...)

    Mots-clés Pascal : Lithiase, Vésicule biliaire, Chimiothérapie, Butyle éther, Dissolution, Voie administration, Efficacité traitement, Récidive, Etude statistique, Homme, Europe, Voie biliaire pathologie, Appareil digestif pathologie

    Mots-clés Pascal anglais : Lithiasis, Gallbladder, Chemotherapy, Dibutylether, Dissolution, Route of administration, Treatment efficiency, Relapse, Statistical study, Human, Europe, Biliary tract disease, Digestive diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0267225

    Code Inist : 002B02H. Création : 11/09/1998.