Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring.
We studied the risk for diabetes of glutamate decarboxylase (GAD65Ab) and islet cell (ICA) autoantibodies in non-diabetic pregnant mothers and their children.
Pregnancy and cord blood sera were collected in 1970-87 from about 35.000 mothers who delivered a child in the city of Malmö, Sweden.
A total of 42 mothers were identified in 1988 who, 1-18 years after their pregnancies, had developed either insulin-dependent (n=22) or non-insulin dependent (n=20) diabetes mellitus.
First, in 123 pregnant mothers selected as controls, 0.8% had GAD65Ab and 0.8% ICA.
Second, among the mothers with non-insulin dependent diabetes, 7/20 (35%) had GAD65Ab eight months to 13 years, 10 months before clinical diagnosis.
Third, in mothers who later developed insulin-dependent diabetes, 12/22 (55%) had GAD65Ab and 10/22 (45%) had ICA in pregnancies preceding the clinical diagnosis by 13 months to 9 years, 4 months.
In 1996, none of the children born to the 42 mothers have developed diabetes.
GAD65Ab and ICA in non-diabetic pregnancies may predict insulin-dependent diabetes in the mother but not necessarily in the offspring.
Mots-clés Pascal : Diabète insulinodépendant, Glutamate decarboxylase, Carboxy-lyases, Carbon-carbon lyases, Lyases, Enzyme, Autoanticorps, Anticorps, Ilot Langerhans, Gestation, Passage transplacentaire, Epidémiologie, Suède, Europe, Homme, Endocrinopathie, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Insulin dependent diabetes, Glutamate decarboxylase, Carboxy-lyases, Carbon-carbon lyases, Lyases, Enzyme, Autoantibody, Antibody, Langerhans islet, Pregnancy, Placental transfer, Epidemiology, Sweden, Europe, Human, Endocrinopathy, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0266491
Code Inist : 002B21E01A. Création : 11/09/1998.