In order to determine if cavum septum pellucidum (CSP) is more prevalent in schizophrenic patients, we studied 72 Japanese patients who fulfilled the DSM-III-R criteria for schizophrenia and 41 normal controls.
Sagittal, 1 mm thick magnetic resonance imaging slices of the entire cranium were obtained using a gradient-echo pulse sequence, and coronal and axial images were reconstructed for assessment.
A CSP was observed in 34 patients (47.2%) and in 16 controls (38.0%). Although the CSP appeared to be more prevalent in schizophrenic patients, this difference was not statistically significant.
However, schizophrenic patients with a history of long-term institutionalization had a higher incidence of CSP compared with patients who had not been admitted to hospital for more than 3 years (68.2 vs 38.0%). These results suggest that the CSP may be a pathophysiology that characterizes schizophrenic patients with poor prognoses.
Mots-clés Pascal : Schizophrénie, Diagnostic and Statistical Manual III, Version revisée, Epidémiologie, Homme, Japonais, Etude comparative, Septum lucidum, Imagerie RMN, Prévalence, Système nerveux central, Encéphale, Stade clinique, Hospitalisation, Psychose, Imagerie médicale, Cavité septum lucidum
Mots-clés Pascal anglais : Schizophrenia, Diagnostic and Statistical Manual III, Revised drafting, Epidemiology, Human, Japanese, Comparative study, Septum lucidum, Nuclear magnetic resonance imaging, Prevalence, Central nervous system, Brain (vertebrata), Clinical stage, Hospitalization, Psychosis, Medical imagery
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0265932
Code Inist : 002B18C06A. Création : 11/09/1998.