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  1. Mortality and diabetes from a population based register in Yorkshire 1978-93.

    Article - En anglais


    --To investigate mortality of children diagnosed with insulin dependent diabetes mellitus (IDDM) and to identify common factors before death.

    Design-Follow up of a population based cohort of children diagnosed with IDDM to ascertain deaths.

    Setting-Children were diagnosed in Yorkshire but followed up throughout the United Kingdom.

    Subjects-From the Yorkshire Children's Diabetes Register details of 1854 children aged 0-16 years (1978-93) were submitted to the NHS Central Register.

    Main outcome measure-Notification and causes of death.


    -98.3% of cases were traced and 26 deaths identified.

    Follow up ranged from 1-18 years (median 9.3 years), providing 17 350 person-years of IDDM.

    Fifteen deaths (58%) were attributed to diabetes or its complications ; 11 (42%) were unrelated and included one suicide.

    For mortality from all causes, the standardised mortality ratio (SMR) of 247 (95% confidence interval (CI) 163 to 362) was significantly increased for those under 34 years.

    The largest number of deaths (n=10) occurred in the 15-19 year age range, with an SMR of 442 (95% CI 209 to 802).

    Case note examination showed a clear tendency towards poor diabetic control, and worries over control were expressed before death by health care professionals.

    Conclusions-Despite advances in treatment, IDDM still carries an increased mortality for young people, particularly in the « transition » age range.

    Mots-clés Pascal : Diabète insulinodépendant, Dépistage, Etude cohorte, Mortalité, Complication, Facteur risque, Enfant, Homme, Royaume Uni, Europe, Evaluation, Endocrinopathie, Immunopathologie, Maladie autoimmune

    Mots-clés Pascal anglais : Insulin dependent diabetes, Medical screening, Cohort study, Mortality, Complication, Risk factor, Child, Human, United Kingdom, Europe, Evaluation, Endocrinopathy, Immunopathology, Autoimmune disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0265756

    Code Inist : 002B21E01B. Création : 11/09/1998.