Urinary levels of alpha1-microglobulin (alpha1M) and of ulinastatin (UT) and the alpha1M/UT ratio did not differ significantly between age-matched controls and patients with Parkinson's disease, and among subdivided groups based on Yahr's stages in Parkinson's disease.
Furthermore, these indexes did not correlate with Yahr's stages.
Although alpha1M and UT levels did not correlate in patients with Parkinson's disease, a positive correlation was observed in the control group.
The non-existence of a positive correlation between alpha1M and UT levels distinguishes Parkinson's disease from other neuropsychiatric diseases such as dementia (Alzheimer-type and vascular dementia), schizophrenia and mood disorder.
Mots-clés Pascal : Parkinson maladie, Homme, Urine, Microglobuline, Age, Epidémiologie, Diagnostic différentiel, Trouble psychiatrique, Concentration, Ulinastatine, Inhibiteur enzyme, Peptidases, Hydrolases, Enzyme, Trypsine, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Extrapyramidal syndrome, Maladie dégénérative
Mots-clés Pascal anglais : Parkinson disease, Human, Urine, Microglobulin, Age, Epidemiology, Differential diagnostic, Mental disorder, Concentration, Ulinastatin, Enzyme inhibitor, Peptidases, Hydrolases, Enzyme, Nervous system diseases, Central nervous system disease, Cerebral disorder, Extrapyramidal syndrome, Degenerative disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0265735
Code Inist : 002B17G. Création : 11/09/1998.