Ten-year (1985-1995) results of an expanded medical surveillance program of 2475 active employees and retirees of an oil refinery and petrochemical complex in Illinois are presented.
At the end of the program, 116 participants with persistent abnormalities of complete blood cell count had been referred for hematologic evaluation, and most were found to have benign conditions.
Fifteen of the 116 were referred for bone marrow and cytogenetic studies.
All of the referred active employees (seven) were found to have completely normal bone marrows with no evidence of any myelopathic process.
Among the eight retirees, two had normal bone marrows, one was diagnosed with Philadelphia chromosome-positive chronic myelogenous leukemia, one declined to participate, and four were diagnosed to have myelodysplastic syndrome (MDS) of various subtypes.
A total of eight cases of MDS were identified, including six cases among program participants and two cases among non participants.
The MDS standardized incidence ratio of 1.26 (95% confidence interval=0.54-2. 4 7) was not statistically significant, and there was virtually no increase of MDS in persons less than 80 years of age (4 observed and 3. 8 expected).
This MDS increase was entirely from program participants, probably because of intensive follow-up and diagnostic screening.
Routine surveillance of complete blood cell count information did not identify any new cases of leukemia or MDS in active employees. (...)
Mots-clés Pascal : Surveillance biologique, Programme sanitaire, Homme, Industrie pétrochimique, Raffinerie, Myélodysplasique syndrome, Leucémie, Hémogramme, Exposition professionnelle, Population active, Retraite, Illinois, Etats Unis, Amérique du Nord, Amérique, Médecine travail, Hémopathie maligne
Mots-clés Pascal anglais : Biological monitoring, Sanitary program, Human, Petrochemical industry, Refinery, Myelodysplastic syndrome, Leukemia, Blood cell count, Occupational exposure, Labour force, Retirement, Illinois, United States, North America, America, Occupational medicine, Malignant hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0265425
Code Inist : 002B19B. Création : 11/09/1998.