Immunosuppression, possibly in combination with viruses, could he a main etiologic mechanism for non-Hodgkin's lymphoma (NHL).
Chemicals such as phenoxyacetic acids, chlorophenols, dioxins, organic solvents, polychlorinated biphenyls, chlordane, and immunosuppressive drugs have been associated with this disease.
Also UV light and blood transfusion have been postulated to be risk factors.
Conclusive evidence of a causal association with NHL is not established for all of these exposures, hut experimental evidence and clinical observations indicate that all these exposures have in common that they may impair the immune system.
Furthermore, acquired and congenital immune deficiency as well as autoimmune disorders increase the risk for NHL.
In view of currently available evidence, the first priority for reducing morbidity due to NHL might he to take action against adverse chemical exposures as a measure that is more easily achievable than any other kind of prevention.
Mots-clés Pascal : Lymphome non hodgkinien, Etiologie, Facteur risque, Composé chimique, Toxicité, Rayonnement UV, Rayonnement solaire, Onde électromagnétique, Immunodépression, Epidémiologie, Homme, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Non Hodgkin lymphoma, Etiology, Risk factor, Chemical compound, Toxicity, Ultraviolet radiation, Solar radiation, Electromagnetic wave, Immunosuppression, Epidemiology, Human, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0265415
Code Inist : 002B19B. Création : 11/09/1998.