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  1. Urinary excretion of arsenic species after exposure to arsenic present in drinking water.

    Article - En anglais

    The water from some drilled wells in southwest Finland contains high arsenic concentrations (min-max : 17-980 mug/L).

    We analyzed inorganic arsenic (As-i) and organic arsenic (monomethylarsonate [MMA] and dimethylarsinate [DMA]) species in urine and conducted a clinical examination of current users (n=35) and ex-users (n=12) of such wells.

    Ex-users had ceased to use the water from the wells 2-4 months previously.

    Urinary arsenic species were also analyzed from persons whose drinking water contained less than 1 mug/L of arsenic (controls, n=9).

    The geometric means of the concentrations of total arsenic in urine were 58 mug/L for current users, 17 mug/L for ex-users, and 5 mug/L for controls.

    The excreted arsenic was associated with the calculated arsenic doses, and on average 63% of the ingested arsenic dose was excreted in urine.

    The ratios of MMA/DMA and As-i/As-tot (As-tot=As-i+MMA+DMA) in urine tended to be lower among the current users and in the higher exposure levels than in controls, suggesting that As-i was better methylated in current users.

    However, the differences were mainly explained by age ; older persons were better methylators of inorganic arsenic than younger individuals.

    The arsenic content of hair correlated well with the past and chronic arsenic exposure ; an increase of 10 mug/L in the arsenic concentration of the drinking water or an increase of 10-20 mug/day of the arsenic exposure corresponded to a 0.1 mg/kg increase in hair arsenic. (...)

    Mots-clés Pascal : Arsenic, Contamination, Eau potable, Finlande, Europe, Homme, Surveillance biologique, Métabolisme, Toxicocinétique, Pharmacocinétique, Excrétion, Marqueur biologique, Relation temps réponse, Cheveu, Epidémiologie, Toxicité, Age

    Mots-clés Pascal anglais : Arsenic, Contamination, Drinking water, Finland, Europe, Human, Biological monitoring, Metabolism, Toxicokinetics, Pharmacokinetics, Excretion, Biological marker, Time response relation, Hair (head), Epidemiology, Toxicity, Age

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0264581

    Code Inist : 002B03H. Création : 11/09/1998.