Changes in airway function and bronchial responsiveness after acute occupational exposure to chlorine leading to treatment in a first aid unit.
Objectives-To describe the baseline characteristics and the time course of changes in lung function in workers accidentally inhaling high concentrations of chlorine in a prospective study.
Methods-Baseline spirometry and methacholine challenge test were performed in a cohort of 278 workers at risk of accidental inhalation of chlorine.
Workers in whom accidental inhalation led to intervention in a first aid unit were reassessed five to 25 days after the accident and serially thereafter when there where notable changes.
During a four year follow up period, 13 workers were seen at the first aid unit after a symptomatic accidental inhalation.
Three of them experienced notable functional changes : one worker experienced a 10% fall in forced expiratory volume in one second (FEV1), and the other two had a notable fall in the concentration of methacholine that caused a 20% fall in FEV1 (PC20).
Two workers were smokers and one had a personal history of atopy.
Baseline assessment was within the normal range in these three workers.
Recovery was complete three months after the accidental inhalation.
Conclusion-Transient but notable decreases in airway function or increases in bronchial responsiveness can occur after an accidental inhalation of high concentrations of chlorine in workers at risk.
Mots-clés Pascal : Chlore, Inhalation, Accident travail, Dose forte, Epidémiologie, Appareil respiratoire pathologie, Fonction respiratoire, Toxicité, Etude cohorte, Homme, Centre premier secours, Etude longitudinale, Médecine travail
Mots-clés Pascal anglais : Chlorine, Inhalation, Occupational accident, High dose, Epidemiology, Respiratory disease, Lung function, Toxicity, Cohort study, Human, First aid center, Follow up study, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0263597
Code Inist : 002B03L06. Création : 11/09/1998.