Epidemiologic studies concerning myelodysplastic syndromes (MDS) are rare.
The estimated incidence varies between 1 and 12.6/100000/year.
The aim of this work was to compare our own experience with these data.
Our general hospital represents a structure with 1197 beds which serves a population of 290 000 individuals (French Basques).
Most of the inhabitants live in a rural environnement.
Twenty percent of the population are aged over 65.
During a 4-year period (1993-1996), 90 new cases of MDS were diagnosed on bone marrow studies in our laboratory.
Among FAB subtypes refractory anemia (RA) represented 27 cases (31%), RA with ring sideroblasts (RARS) : 21 (23%), RA with excess of blasts (RAEB) and in transformation (RAEB-t) : 22 (24%), chronic myelomonocytic leukemia (CMML) : 10 (11%). Ten cases were unclassifiable (11%). Therapy-related MDS were seen in 8 patients.
The sex ratio was 1 and the mean age of the patients was 74.3 (range : 23-96), 37% of them being 80 years or older.
The calculated incidence was 7.7/100 000/year for the entire cohort and 31.4/100 000/year for people over 65.
Mots-clés Pascal : Myélodysplasique syndrome, Incidence, Epidémiologie, Hôpital général, France, Europe, Homme, Hémopathie maligne, Pays basque
Mots-clés Pascal anglais : Myelodysplastic syndrome, Incidence, Epidemiology, General hospital, France, Europe, Human, Malignant hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0262319
Code Inist : 002B19B. Création : 11/09/1998.