Screening for human T cell leukaemia/lymphoma virus among blood donors in Sweden : cost effectiveness analysis.
To analyse the cost effectiveness of a national programme to screen blood donors for infection with the human T cell leukaemia/lymphoma virus.
Three models for calculating the costs and benefits of screening were developed.
The first model analysed the cost of continuously testing all donations ; the second analysed the cost of initially testing new blood donors and then retesting them after five years ; the third analysed the cost of testing donors only at the time of their first donation.
Patients who had received blood components from donors confirmed to be infected with the virus were offered testing.
Main outcome measures
Prevalence of infection with the virus among blood donors, the risk of transmission of the virus, screening costs, and the outcome of infection.
648 497 donations were tested for the virus ; 1625 samples tested positive by enzyme linked immunosorbent assay. 6 were confirmed positive by western blotting.
The prevalence of infection with the virus was 2/100 000 donors. 35 patients who had received blood infected with the virus were tested ; 3 were positive.
The cost of testing every donation was calculated to be $3.02m (£1.88m) ; this is 18 times higher than the cost of testing new donors only, and only 1 additional positive donor would be discovered in 7 years.
Regardless of the model used, screening was estimated to prevent only 1 death every 200 years at a minimum cost of $36m (£22.5m). (...)
Mots-clés Pascal : Virus HTLV, Retroviridae, Virus, Virose, Infection, Don sang, Donneur sang, Dépistage, Diagnostic, Analyse coût efficacité, Homme, Economie santé, Suède, Europe, Transfusion
Mots-clés Pascal anglais : HTLV virus, Retroviridae, Virus, Viral disease, Infection, Blood donation, Blood donor, Medical screening, Diagnosis, Cost efficiency analysis, Human, Health economy, Sweden, Europe, Transfusion
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0262101
Code Inist : 002B05C02E. Création : 11/09/1998.