Incidence of seroconversion to positivity for hepatitis C antibody in repeat blood donors in England, 1993-5.
To estimate the rate of seroconversion to positivity for hepatitis C antibody in repeat blood donors in England and to describe the probable routes of infection in these donors.
Retrospective survey of blood donors becoming positive for hepatitis C antibody and of the results of donation testing.
The 14 blood centres in England.
All repeat donors giving blood between January 1993 and December 1995.
Main outcome measures
Number of donors developing hepatitis C between donations during the three years of testing for hepatitis C antibody at English blood centres and the rate of seroconversion among repeat blood donors.
Probable routes of infection.
14 donors during 1993-5 fulfilled the case definition for seroconversion to positivity for hepatitis C antibody.
The estimated seroconversion rate for infection with hepatitis C in repeat donors was 0.26 per 100 000 person years (95% confidence interval 0.15 to 0.43).
Counselling after diagnosis found that four of these donors had risk factors specified in the criteria excluding people from giving blood but these factors had not come to light before donation.
Another of the donors who seroconverted had a risk factor that has since been included in the exclusion criteria.
Heterosexual intercourse was considered to be the most likely route of infection for five of the 14 donors. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Sérologie, Anticorps, Séropositivité, Don sang, Donneur sang, Epidémiologie, Incidence, Homme, Angleterre, Grande Bretagne, Royaume Uni, Europe, Appareil digestif pathologie, Foie pathologie, Transfusion
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Serology, Antibody, Seropositivity, Blood donation, Blood donor, Epidemiology, Incidence, Human, England, Great Britain, United Kingdom, Europe, Digestive diseases, Hepatic disease, Transfusion
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0262100
Code Inist : 002B05C02G. Création : 11/09/1998.