To ascertain the prevalence of the diffuse infiltrative lymphocytosis syndrome (DILS) in human immunodeficiency virus type 1 (HIV-1) - positive outpatients.
The presence of sicca symptoms and visible salivary gland enlargement was determined by interview and physical examination, and the clinical stage was determined by chart review, in 523 HIV-positive patients.
The diagnosis of DILS was established in those with parotid gland enlargement by minor salivary gland biopsy or radionuclide scintigraphy.
Definite DILS was found in 15 (3%) of the 523 patients, and possible DILS in 18 (3.4%). The prevalence of definite DILS was significantly higher in African Americans (4.5%). Self-reported facial swelling and xerophthalmia that was not explained by the effects of medication were found more frequently in those with DILS than in the non-DILS patients.
Patients with DILS had higher CD8 counts (mean ± SD 1,456 ± 813/mm3) compared with those without DILS (934 ± 624/mm3 ; P<1 x 10-6), and were less advanced in their HIV clinical stage (Centers for Disease Control and Prevention stages A or B in 76% compared with 60% of the non-DILS group ; P=0.01).
DILS is an important problem in HIV-infected outpatients and tends to occur in patients whose clinical disease is at a less advanced stage.
Patients with parotid gland enlargement accompanied by sicca symptoms should be screened for HIV infection.
Mots-clés Pascal : Immunodéficit, Infection, Virus HIV1, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Epidémiologie, Prévalence, Association, Syndrome, Lymphocytose, Symptomatologie, Homme, Ambulatoire, Immunopathologie, Virose, Oeil pathologie, Glande salivaire pathologie, Syndrome sec Gougerot
Mots-clés Pascal anglais : Immune deficiency, Infection, HIV-1 virus, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Epidemiology, Prevalence, Association, Syndrome, Lymphocytosis, Symptomatology, Human, Ambulatory, Immunopathology, Viral disease, Eye disease, Salivary gland disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0261680
Code Inist : 002B05C02D. Création : 11/09/1998.