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  1. The influence of sex on the phenotype of rheumatoid arthritis.

    Article - En anglais


    To explore whether there are different disease patterns of rheumatoid arthritis (RA) in women and men.


    We studied 55 male case patients and 110 female control patients who developed RA between 1970 and 1985 and who resided and received medical care in Olmsted County, Minnesota, for at least 10 years after the diagnosis of RA.

    Case and control patients were matched for the date of first diagnosis.

    The pattern and extent of joint involvement, the frequency of joint surgeries, and the presence and type of extraarticular manifestations were determined by retrospective chart review.


    Incidence rates in women were variable and age dependent, whereas the risk in men older than 36 years was constant over their lifetime.

    Erosive disease was more frequent in men than in women (72% versus 55%, respectively ; P<0.05) and tended to occur earlier (47% versus 31% for erosive disease within the first 4 years of RA).

    Although male sex was correlated with a higher risk of bony erosions and an accelerated course of RA, structural consequences of joint destruction were more pronounced in women.

    Joint surgery was performed more frequently in women (50%) than in men (27%) (P=0.01).

    In particular, the frequencies of arthroplasties and arthrodeses of hand and foot joints were different (34 procedures in women versus 1 procedure in men ; P<0.001).

    Sex influenced the risk as well as the pattern of organ involvement in RA. (...)

    Mots-clés Pascal : Polyarthrite rhumatoïde, Phénotype, Homme, Déterminisme génétique, Facteur risque, Sexe, Epidémiologie, Incidence, Evolutivité, Symptomatologie, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune

    Mots-clés Pascal anglais : Rheumatoid arthritis, Phenotype, Human, Genetic determinism, Risk factor, Sex, Epidemiology, Incidence, Evolutivity, Symptomatology, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0261674

    Code Inist : 002B15D. Création : 11/09/1998.