To assess whether the adequate antibody response observed in former extremely premature infants after the primary series of immunizations is sustained after the first booster vaccines.
Sixteen former extremely premature (<29 weeks,<1000 g at birth) and 17 former full-term (>37 weeks) infants had sera obtained for antibody titer measurement at 3 to 4 years of age.
All had received the primary series and first booster vaccines for diphtheria, pertussis, tetanus, polio, and Haemophilus influenzae type b. Twelve preterm and 14 full-term children had completed the hepatitis B vaccine series.
At 3 to 4 years of age, former preterm and full-term children had similar geometric mean titer (GMT) values of antibodies to tetanus, diphtheria, and pertussis.
Preterm children had a lower GMT value of Haemophilus polyribosylribitol phosphate (PRP) antibody than did full-term children (0.99 vs 3.06 mug/mL).
Fifty percent of preterm and 88% of full-term children had PRP antibody>1.0 mug/mL ; 100% of preterm and 94% of full-term children had anti-PRP titers>0.15 mug/mL.
GMT values of neutralizing antibodies to polio serotypes 1 and 2 were similar, with 94% to 100% of both groups above protective levels (=l : 8).
The difference in GMT values of polio serotype 3 approached significance (29 vs 73) ; fewer preterm children had protective titer values (75% vs 100%). (...)
Mots-clés Pascal : Vaccination, Nourrisson, Homme, Prématuré, Réponse immune, Etude longitudinale, Anticorps, Evaluation, Facteur efficacité, Immunoprophylaxie, Immunologie, Politique sanitaire
Mots-clés Pascal anglais : Vaccination, Infant, Human, Premature, Immune response, Follow up study, Antibody, Evaluation, Effectiveness factor, Immunoprophylaxis, Immunology, Health policy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0261313
Code Inist : 002B05A02. Création : 11/09/1998.