Three-year follow-up of vaccine response in extremely preterm infants.
To assess whether the adequate antibody response observed in former extremely premature infants after the primary series of immunizations is sustained after the first booster vaccines.
Subjects and Methods
Sixteen former extremely premature (<29 weeks,<1000 g at birth) and 17 former full-term (>37 weeks) infants had sera obtained for antibody titer measurement at 3 to 4 years of age.
All had received the primary series and first booster vaccines for diphtheria, pertussis, tetanus, polio, and Haemophilus influenzae type b. Twelve preterm and 14 full-term children had completed the hepatitis B vaccine series.
At 3 to 4 years of age, former preterm and full-term children had similar geometric mean titer (GMT) values of antibodies to tetanus, diphtheria, and pertussis.
Preterm children had a lower GMT value of Haemophilus polyribosylribitol phosphate (PRP) antibody than did full-term children (0.99 vs 3.06 mug/mL).
Fifty percent of preterm and 88% of full-term children had PRP antibody>1.0 mug/mL ; 100% of preterm and 94% of full-term children had anti-PRP titers>0.15 mug/mL.
GMT values of neutralizing antibodies to polio serotypes 1 and 2 were similar, with 94% to 100% of both groups above protective levels (=l : 8).
The difference in GMT values of polio serotype 3 approached significance (29 vs 73) ; fewer preterm children had protective titer values (75% vs 100%). (...)
Mots-clés Pascal : Vaccination, Nourrisson, Homme, Prématuré, Réponse immune, Etude longitudinale, Anticorps, Evaluation, Facteur efficacité, Immunoprophylaxie, Immunologie, Politique sanitaire
Mots-clés Pascal anglais : Vaccination, Infant, Human, Premature, Immune response, Follow up study, Antibody, Evaluation, Effectiveness factor, Immunoprophylaxis, Immunology, Health policy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0261313
Code Inist : 002B05A02. Création : 11/09/1998.