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  1. Estimates of the discriminant ability of definitions of improvement for juvenile rheumatoid arthritis.

    Article - En anglais


    To investigate the ability of various definitions of improvement to distinguish between patients with juvenile rheumatoid arthritis (JRA) treated with active drug from those given placebo in randomized trials.


    A core set of 6 response (outcome) variables for use in JRA has been reported.

    These core variables were combined into a number of « definitions of improvement » for the purpose of classifying individual patients as either « clinically significantly improved » or « not improved. » We used a large dataset from randomized controlled trials to test the discriminant ability (sensitivity to change) of the definitions.

    We calculated the proportion of patients classified as « improved » by each definition in each of the treatment and control groups.


    Effect sizes were weak in 4 of the treatment regimens used (D-penicillamine, hydroxychloroquine, auranofin, and very low dose methotrexate) and no definition discriminated well between drug and placebo treated groups.

    Definitions that required 20 to 30% improvement in 3 to 4 of the 6 core set variables showed statistically significant differences in the proportions of patients who were classified as improved in the group treated with low dose methotrexate (10 mg/m2 body surface area/wk) compared to placebo. (...)

    Mots-clés Pascal : Arthrite chronique juvénile, Chimiothérapie, Antimétabolite, Méthotrexate, Auranofine, Pénicillamine, Evaluation, Evolution, Amélioration, Définition, Evaluation performance, Enfant, Homme, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire

    Mots-clés Pascal anglais : Juvenile rheumatoid arthritis, Chemotherapy, Antimetabolic, Methotrexate, Auranofin, Penicillamine, Evaluation, Evolution, Improvement, Definition, Performance evaluation, Child, Human, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0260867

    Code Inist : 002B15D. Création : 11/09/1998.