Background It has been suggested that prenatal exposure to maternal stress ncreases the risk of subsequently developing schizophrenia.
Method The five-day nvasion and defeat of The Netherlands by the German army in May 1940 constituted a severe. well-circumscribed rational stressful event.
Individuals exposed and non-exposed to this stressor in the first. second and third trimester of pregnancy were followed up for lifetime schizophrenia outcome through the National Psych atric Case Register.
Register Cumulative incidence of schizophrenia was higher in the exposed cohort (risk ratio (RR) : 1.15. 95% Cl : 1.03-1.28), especially in those exposed n the first trimester (RR : 1.28. 95% Cl : 07 1.53).
Significant interaction with gender was apparent in second trimester exposed cohorts (RR men : 1.35. 95% Cl. 1.05 1.74 : RR women : 0.83. 95% Cl : 0.61-1.12).
Conclusion Maternal stress during pregnancy may contribute to the development of vulnerability to schizophrenia The apparent longer window of exposure in male foetuses may be related to the slower pace of male early cerebral development.
Mots-clés Pascal : Schizophrénie, Facteur risque, Exposition, Prénatal, Stress, Gestation, Guerre, Pays Bas, Europe, Etude cohorte, Incidence, Epidémiologie, Santé mentale, Homme, Psychose
Mots-clés Pascal anglais : Schizophrenia, Risk factor, Exposure, Prenatal, Stress, Pregnancy, War, Netherlands, Europe, Cohort study, Incidence, Epidemiology, Mental health, Human, Psychosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0254915
Code Inist : 002B18C06A. Création : 11/09/1998.