The effects of interaction between familial and reproductive factors on breast cancer risk : a combined analysis of seven case-control studies.
In this paper, a combined analysis was performed to study the interaction between familial risk and reproductive life factors.
In particular, the interaction between familial risk and breast cell mitotic activity (BCMA), as assessed by duration of ovarian activity, was investigated because of the potential importance of mitotic activity on genetically susceptible cells.
The present analysis included 3152 cases and 4404 controls in seven case-control studies from four countries.
The interaction effect was estimated in each study separately, then combined using two different methods : a multivariate weighted average and a Bayesian random-effects model.
The main effects of reproductive life factors on the risk of breast cancer were in agreement with the previous findings.
In particular, an increased duration of BCMA before the first childbirth and over life was found to increase the risk of breast cancer (P<0.001).
Slightly increasing but non-significant, familial risks were observed with increasing number of children (P=0.17), increasing age at first childbirth (P>0.2) and increasing duration of BCMA (P>0.2).
There was no modification in familial risk with age at menarche and no clear pattem with menopause characteristics.
A weak influence of reproductive and menstrual factors on the familial risk emerged from the present study.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Facteur risque, Epidémiologie, Histoire familiale, Reproduction, Etude cas témoin, France, Europe, Australie, Océanie, Russie, Eurasie, Singapour, Asie, Homme, Glande mammaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Risk factor, Epidemiology, Family story, Reproduction, Case control study, France, Europe, Australia, Oceania, Russia, Eurasia, Singapore, Asia, Human, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0254747
Code Inist : 002B20E02. Création : 11/09/1998.