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  1. Psychiatric hospital utilization in patients treated with clozapine for up to 4.5 years in a state mental health care system.

    Article - En anglais


    We wished to study long-term psychiatric hospital utilization in a large sample of patients with schizophrenia and/or schizoaffective disorders who were treated with clozapine for up to 4.5 years, and to determine whether or not the reduction in hospital utilization we previously observed in smaller groups for up to 2.5 years was sustained with larger groups and in the longer term.


    Patients in Texas state hospitals who had schizophrenia and/or schizoaffective disorder took either clozapine or traditional antipsychotics for 1.5 to 4.5 years.

    The number of patients in the clozapine group ranged from 383 (1.5 years of treatment) to 29 (4.5 years).

    The group of patients who took traditional antipsychotics was made up of all patients (N=233) with similar diagnoses, symptom severity, and duration of illness present in Texas state hospitals on an index day.


    The clozapine group showed a rapid and continuing decrease in hospital bed-days compared with controls who took traditional antipsychotics.

    The number of clozapine-treated patients who required little or no hospitalization during successive 6-month periods became significant (p<. 0001) within 1.5 years, and continued to increase.

    Conversely, the number of patients taking clozapine who required virtually continuous state hospitalization decreased markedly compared with those taking traditional antipsychotics. (...)

    Mots-clés Pascal : Schizophrénie, Etude comparative, Psychose schizoaffective, Utilisation, Service santé, Hospitalisation, Hôpital psychiatrique, Secteur public, Texas, Etats Unis, Amérique du Nord, Amérique, Analyse coût, Economie santé, Enquête, Etude longitudinale, Santé mentale, Homme, Psychose

    Mots-clés Pascal anglais : Schizophrenia, Comparative study, Schizoaffective psychosis, Use, Health service, Hospitalization, Psychiatric hospital, Public sector, Texas, United States, North America, America, Cost analysis, Health economy, Survey, Follow up study, Mental health, Human, Psychosis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0253841

    Code Inist : 002B02B03. Création : 11/09/1998.