Association of prostate cancer with vitamin D receptor haplotypes in African-Americans.
In previous studies, allelic variation in the 3'end of the vitamin D receptor gene was associated with increased risk of prostate cancer in white men.
Several polymorphisms, including a Bsml restriction site and a poly (A) microsatellite, can be used interchangeably to mark the unidentified locus in whites.
In African-Americans, however, these markers are not interchangeable, due to weaker linkage disequilibrium in this genomic region in this population.
Here, we genotyped both the Bsml and poly (A) markers for 151 African-American prostate cancer cases (102 localized and 49 advanced) and 174 African-American male controls from a large epidemiological cohort.
A direct haplotyping procedure was devised to determine BsmIpoly (A) haplotypes for double heterozygotes so that haplotypes could be used as allelic markers in standard logistic regression analyses.
Using Bsml alone, b alleles were associated with a 2-fold decrease in risk of advanced prostate cancer.
The association was, however, confined to haplotypes carrying a long (L) allele of the poly (A) microsatellite.
BL and bL haplotypes were associated with increased and decreased risk, respectively, whereas neither BS nor bS haplotypes were associated with prostate cancer risk.
An allelic variant that confers increased risk of advanced prostate cancer appears to be associated with the BsmUpoly (A) BL haplotype in African-Americans.
Mots-clés Pascal : Vitamine D, Récepteur biologique, Haplotype, Tumeur maligne, Prostate, Homme, Race, Noir américain, Epidémiologie, Etude cohorte, Génotype, Prédisposition, Facteur risque, Génétique, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie, Polymorphisme, Gène, Gène Vitamin D Receptor
Mots-clés Pascal anglais : Vitamin D, Biological receptor, Haplotype, Malignant tumor, Prostate, Human, Race, Black American, Epidemiology, Cohort study, Genotype, Predisposition, Risk factor, Genetics, Male genital diseases, Urinary system disease, Prostate disease, Polymorphism, Gene
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0253817
Code Inist : 002B14D02. Création : 11/09/1998.