Background Primary liver cancer is an important health problem in Korea, where hepatitis B virus (HBV) infection is prevalent.
The authors conducted a prospective cohort study to evaluate the protective effect of HBV vaccination against liver cancer in adults.
Methods A total of 370 285 males aged =30 comprised the study population.
They were clinically free of liver diseases, and had not been vaccinated against HBV at enrolment.
The results of HBV surface antigen (HBsAg) and antibody to HBsAg (anti-HBs) marker positivity and those of the vaccination programme which took place during 1985 were used for the construction of the cohort.
About 5% (n=18 914) were HBsAg positive, 78 094 were anti-HBs positive, and 273 277 were negative for both.
Among the candidates for HBV vaccination (n=273 277), 35 934 (13.2%) people had been vaccinated against HBV during 1985.
Cases of liver cancer were ascertained by record linkage and from medical records covering 1986-1989.
A multivariate log-linear model was used to test statistical significance and to estimate relative risks (RR).
Results The total follow-up period was 1 404 566 person-years, with an average of 3 years and 10 months.
A total of 302 incident cases were ascertained.
The overall incidence rate of liver cancer was 21.7 per 100 000 person-years. (...)
Mots-clés Pascal : Hépatite virale B, Virose, Infection, Vaccination, Tumeur maligne, Foie, Prévention, Risque, Epidémiologie, Evaluation, Prévalence, Adulte, Homme, Mâle, Corée, Asie, Etude cohorte, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis B, Viral disease, Infection, Vaccination, Malignant tumor, Liver, Prevention, Risk, Epidemiology, Evaluation, Prevalence, Adult, Human, Male, Korea, Asia, Cohort study, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0251624
Code Inist : 002B05C02G. Création : 11/09/1998.