Background To assess the association between the CD4 count and clinical diseases in a cohort of Thai patients.
Methods In all, 1902 patients who presented with human immunodeficiency virus (HIV) infection at the Chulalongkorn University Hospital in Bangkok were investigated.
Results At the time of presentation 295 (15.5%) patients had acquired immunodeficiency syndrome (AIDS) and there was a highly significant tendency for lower CD4 counts in this group (median 67/mm3) than in patients free of AIDS (median 369/mm3).
A total of 757 patients had data available on follow-up and were free of AIDS at the first visit.
During a median follow-up of 0.9 years, 110 developed AIDS or AIDS-related death (12.2/100 person years).
Subjects with CD4 count<200/mm3 at initial visit showed over a ninefold increase in risk of developing AIDS compared to subjects with levels =500/mm3 (relative risk [RR]=9.1 ; 95% CI : 5.4-16.0).
The rate/100 person years was 47.1 compared with 6.0 in subjects with levels =500/mm3.
After adjusting for initial CD4 count, homosexual ten showed over a twofold increase in risk of developing AIDS compared to heterosexuals (RR=2.4 ; 95% CI : 1.6-4.4) and intravenous drug users (IVDU) showed nearly a twofold increase (RR=1.8 ; 95% CI : 0.9-3.9).
The increased risk in homosexual ten persisted even after further adjustment for clinical stage (RR=2.2 ; 95% CI : 1.3-3.7) but the increased risk in IVDU was attenuated (RR=1.5 ; 95% CI : 0.7-3. (...)
Mots-clés Pascal : SIDA, Virose, Infection, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Immunologie, Lymphocyte, Taux, Symptomatologie, Epidémiologie, Incidence, Facteur risque, Homme, Thaïlande, Asie, Immunopathologie, Immunodéficit, Antigène CD4
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Immunology, Lymphocyte, Rate, Symptomatology, Epidemiology, Incidence, Risk factor, Human, Thailand, Asia, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0251619
Code Inist : 002B06D01. Création : 11/09/1998.