Background Night blindness (XN) is the most common clinical symptom of vitamin A deficiency among children in developing countries.
Yet little is known about the aetiology or associated risks of maternal XN.
Emerging evidence from South East Asia suggests that it may be more frequent than previously thought in women of reproductive age, especially during pregnancy.
Methods A population-based, case-control study was conducted to reveal the epidemiology of XN among pregnant Nepali women.
Night blind cases were identified by history through a weekly community surveillance system.
Controls were randomly selected from a pool of pregnant women without XN and pair-matched for gestational age of the cases.
A home-based assessment was done within a week of selection, at which 7-day food frequency and morbidity histories were collected, anthropometry measured, and capillary blood drawn for serum retinol, 5-carotene and haemoglobin (Hb) estimation.
Results Cases and controls did not differ by age or number of previous pregnancies.
However, cases were more likely to be from the lower castes, be illiterate, live in poorer quality homes, and own no land.
The mean serum retinol level of cases was ~0.30 mumol/l lower than controls (P<0.001), indicating a low vitamin A status of night blind pregnant women.
Mean Hb level was significantly lower (by 0.7 g/dl, P<0.004), and the risk of severe anaemia (Hb<7.0 g/dl) higher among cases than controls (odds ratio=3.0,95% CI : 1.25-7.23). (...)
Mots-clés Pascal : Héméralopie, Gestation, Déficit, Rétinol, Régime alimentaire, Epidémiologie, Facteur risque, Homme, Femelle, Népal, Asie, Zone rurale, Etude cas témoin, Oeil pathologie, Trouble vision, Alimentation
Mots-clés Pascal anglais : Night blindness, Pregnancy, Deficiency, Retinol, Diet, Epidemiology, Risk factor, Human, Female, Nepal, Asia, Rural area, Case control study, Eye disease, Vision disorder, Feeding
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0251611
Code Inist : 002B09K. Création : 11/09/1998.