Our study assessed the factors associated with cervical squamous intra-epithelial lesions (SILs) and invasive cervical cancer, with special attention to human immunodeficiency virus (HIV) and human papillomavirus (HPV) infections.
Women from 3 outpatient gynecology clinics of Abidjan, Côte d'lvoire, were screened for cervical abnormalities : 151 women with low-grade SILs and 151 controls, 60 with high-grade SILs and 240 controls, and 13 with invasive cancer and 65 controls were enrolled in 3 case-control studies.
Controls were chosen at random among the women without lesions, with a frequency matching for age and center.
We used the PCR method for the detection of cervical HPV DNA and the restriction fragment length polymorphism analysis for HPV typing.
HIV antibody testing and CD4 cell count were performed.
In multivariate analyses, factors associated with cervical lesions were :
for low-grade SILS,
HIV-I seropositivity and parity>3 ;
for high-grade SILs,
HPV positivity, chewing tobacco,
HIV-I seropositivity and illiteracy, and for invasive cancer,
HPV positivity only.
We found a diversity of HPV types associated with SILs.
In HIV-I-infected women, SILs occurred at an early stage of HIV disease.
Women infected with both HIV-I and HPV were at much higher risk of SILs than women infected with each of these 2 viruses separately.
Invasive cancer was linked to HIV-2 infection in univariate analysis only. (...)
Mots-clés Pascal : Tumeur maligne, Col utérus, Dysplasie, Virose, Infection, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, SIDA, Facteur risque, Epidémiologie, Côte d'Ivoire, Afrique, Homme, Appareil génital femelle pathologie, Col utérus pathologie, Lésion précancéreuse, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : Malignant tumor, Uterine cervix, Dysplasia, Viral disease, Infection, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, AIDS, Risk factor, Epidemiology, Ivory Coast, Africa, Human, Female genital diseases, Uterine cervix diseases, Premalignant lesion, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0249222
Code Inist : 002B20C02. Création : 11/09/1998.