In Sapporo City a mass screening program for neuroblastoma targeting children age 6 months (6-MS) was initially introduced in 1981.
Since April 1991, an additional program has been implemented, aimed at children age 14 months (14-MS).
High performance liquid chromatography was employed in the 14-MS.
Identification of cases was dependent on the Registry of Childhood Malignancies in the Hokkaido Prefecture.
Of the 85,783 live births in Sapporo City during the period 1990-1994, a total of 56,444 participated in the 14-MS (compliance rate, 65.8%). By the end of 1996, of 48,448 children who had previously taken part in the 6-MS, 6 cases were identified in the 14-MS, and 1 additional case screened negative but was later diagnosed clinically.
Two more cases were detected in the 14-MS among the 7996 children who had not participated in the 6-MS.
Though the incidence of cases identified by the 14-MS was much higher than expected, several true-positive cases had unfavorable histology (as defined by Shimada's classification), a high dopamine level, and/or a high homovanillic acid/vanillylmandelic acid ratio.
Mass screening of children age 14 months for neuroblastoma detects cases missed or unscreened at age 6 months, though the detection rate appears to be in excess of what would be expected from natural incidence.
Mots-clés Pascal : Neuroblastome, Programme sanitaire, Dépistage, Epidémiologie, Age, Japon, Asie, Enfant, Homme, Système nerveux pathologie, Système nerveux sympathique pathologie, Tumeur maligne
Mots-clés Pascal anglais : Neuroblastoma, Sanitary program, Medical screening, Epidemiology, Age, Japan, Asia, Child, Human, Nervous system diseases, Autonomic neuropathy, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0249215
Code Inist : 002B17E. Création : 11/09/1998.