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  1. Mass screening for neuroblastoma targeting children age 14 months in Sapporo City : A preliminary report.

    Article - En anglais

    BACKGROUND

    In Sapporo City a mass screening program for neuroblastoma targeting children age 6 months (6-MS) was initially introduced in 1981.

    Since April 1991, an additional program has been implemented, aimed at children age 14 months (14-MS).

    METHODS

    High performance liquid chromatography was employed in the 14-MS.

    Identification of cases was dependent on the Registry of Childhood Malignancies in the Hokkaido Prefecture.

    RESULTS

    Of the 85,783 live births in Sapporo City during the period 1990-1994, a total of 56,444 participated in the 14-MS (compliance rate, 65.8%). By the end of 1996, of 48,448 children who had previously taken part in the 6-MS, 6 cases were identified in the 14-MS, and 1 additional case screened negative but was later diagnosed clinically.

    Two more cases were detected in the 14-MS among the 7996 children who had not participated in the 6-MS.

    Though the incidence of cases identified by the 14-MS was much higher than expected, several true-positive cases had unfavorable histology (as defined by Shimada's classification), a high dopamine level, and/or a high homovanillic acid/vanillylmandelic acid ratio.

    CONCLUSIONS

    Mass screening of children age 14 months for neuroblastoma detects cases missed or unscreened at age 6 months, though the detection rate appears to be in excess of what would be expected from natural incidence.

    Mots-clés Pascal : Neuroblastome, Programme sanitaire, Dépistage, Epidémiologie, Age, Japon, Asie, Enfant, Homme, Système nerveux pathologie, Système nerveux sympathique pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Neuroblastoma, Sanitary program, Medical screening, Epidemiology, Age, Japan, Asia, Child, Human, Nervous system diseases, Autonomic neuropathy, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0249215

    Code Inist : 002B17E. Création : 11/09/1998.