The role of the general clinical research center in promoting patient-oriented research into the mechanisms of disease.
Patient-and proband-oriented research (POR) into the mechanisms of disease has been most successful in the United States over the past 50 years.
To foster POR in universities across the country the National Institutes of Health (NIH) instituted 5-year renewable competitive grants for the establishment of General Clinical Research Centers (GCRCs).
The number of GCRCs grew from 5 in 1960 to a maximum of 93 in 1969.
Currently 74 GCRCs are in operation at 47 of more than 120 medical schools in the United States.
They range in size from 4 to 30 beds, with an average of about 10.
Each GCRC supports a Program Director, diet kitchens, core laboratory, biostatistical and computing support, nursing staff, and an administrative assistant.
The GCRC is available to enable and facilitate POR of faculty investigators based at the parent university.
Investigators make applications to the GCRC for support of a given project, the project is evaluated by the GCRC institutional advisory committee and ethics committee, and if found acceptable the resources of the GCRC including bed space, nursing support, laboratory, and statistical capabilities are made available.
The GCRC grant supplies the university with overhead support, but more importantly GCRC-supported investigators regularly bring in grant support from NIH far and above that provided by the GCRC grant itself. (...)
Mots-clés Pascal : Centre recherche, Recherche fondamentale, Organisation, Centre hospitalier universitaire, Médecine, Etats Unis, Amérique du Nord, Amérique, Investissement public, Subvention, Recherche clinique, National Institute of Health
Mots-clés Pascal anglais : Research center, Fundamental research, Organization, Teaching hospital, Medicine, United States, North America, America, Public investment, Subsidy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0248191
Code Inist : 002B30A04A. Création : 11/09/1998.