The shift in prevalence of hepatitis A immunity in Flanders, Belgium.
The purpose of this study was to obtain data on the prevalence of hepatitis A in Flanders, Belgium, in order to analyse any change in the epidemiological pattern of hepatitis A virus (HAV) in the region, and to determine at which age pre-vaccination testing would be useful.
To meet these goals, a sero-epidemiological survey was conducted : 4058 serum samples were collected from a random sample of the general population in 1993-94.
The overall age-standardised prevalence was 51.3%. Among non-Belgians (N=245), the age-standardised anti-HAV prevalence was 66.4%, significantly higher than the 49.6% anti-HAV prevalence found in Belgians (N=3186).
Among Belgians, seroprevalence increased with age : from 5.4% in the youngest age group (0-14 years) to over 80% in the two oldest age groups (55-64 years and = 65 years).
Prevalence rates were as high as 31.7% in the 25-34 year old age category, and 60.8% in the 35-44 year old age category.
The age-specific prevalence figures among Belgians and non-Belgians reflect two different epidemiological patterns : the epidemiological pattern of a low endemic region for Belgians and the epidemiological profile of an intermediate endemic region for non-Belgians.
The age-specific prevalence figures in Belgians were compared with the 1979 and 1989 anti-HAV prevalence figures in Belgian first-time blood donors.
A clear epidemiological shift showing decreasing HAV prevalence in the youngest age groups was found. (...)
Mots-clés Pascal : Hépatite virale A, Virose, Infection, Epidémiologie, Prévalence, Sérologie, Evaluation, Homme, Belgique, Europe, Appareil digestif pathologie, Foie pathologie, Immunopathologie
Mots-clés Pascal anglais : Viral hepatitis A, Viral disease, Infection, Epidemiology, Prevalence, Serology, Evaluation, Human, Belgium, Europe, Digestive diseases, Hepatic disease, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0248148
Code Inist : 002B05C02G. Création : 11/09/1998.