The aim of this study was to evaluate whether toluene, like many other organic solvents and solvent mixtures, could impair color vision.
We investigated color vision impairment in three groups of workers, two groups occupationally exposed to toluene and a nonexposed group.
The first exposed group, group E1, comprised 41 workers (median value of toluene in air 35.00 ppm, range 11.3-49.3 ppm) and the second exposed group, group E2, comprised 32 subjects (median value of toluene in air 156.00 ppm, range 66.0-250.0 ppm).
The nonexposed group, group NE, comprised 83 subjects.
Color vision was evaluated by the Lanthony D-15 desaturated test according to Verriest's classification : type I, loss in the red-green range ; type II, loss in the blue-yellow and red-green ranges, and type III, loss in the blue-yellow range.
Subjects were classified as dyschromates if specific acquired loss was determined in at least one eye.
In both exposed groups, exposure was evaluated by measurement of the concentration of toluene in the ambient air and in the blood.
In group E2, level of hippuric acid and orthocresol in urine after the work shift were also determined.
The Mann-Whitney U-test, t-test, X2-test, and Spearman's rank correlation and multiple regression analysis were used for statistical analysis.
Type III dyschromatopsia was detected in all groups examined : 26.6% of the workers in group NE, 31. (...)
Mots-clés Pascal : Toluène, Solvant organique, Toxicité, Trouble vision, Vision couleur, Dyschromatopsie, Homme, Exposition professionnelle, Médecine travail, Oeil pathologie
Mots-clés Pascal anglais : Toluene, Organic solvent, Toxicity, Vision disorder, Color vision, Dyschromatopsia, Human, Occupational exposure, Occupational medicine, Eye disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0247581
Code Inist : 002B03L04. Création : 11/09/1998.