The nutrition management of patients with malabsorption syndromes due to acquired immunodeficiency syndrome (AIDS) is problematic.
The aim of this study was to compare the effects of total parenteral nutrition (TPN) and an oral, semielemental diet (SED) on body weight, body composition, quality of life, survival, and medical costs in AIDS patients with malabsorption.
This was a prospective, randomized, open-label study performed in outpatients.
Twenty-three AIDS subjects (TPN group, 12 ; SED group, 11) with cryptospcridiosis, microsporidiosis, or malabsorption of unknown cause were randomized and followed.
Subjects were prescribed equivalent amounts of formulas of similar composition for 3 months.
Monthly estimations of caloric intake, body weight, body composition by bioimpedance analysis, and quality of life were recorded.
Nutritional variables were analyzed by repeated-measures analysis of covariance, with the baseline measure as the covariate.
Nutrition-related medical costs, survival, and indices of absorptive and immune function were compared, Results : Subjects had lost an average of 1.5 and 1.0 kg body wt/mo for TPN and SED during the 6 months before study entry (p The TPN group consumed more total calories than the SED group (p<. 05). Weight change during therapy was significantly different from pretreatment in both groups (p<. 01 for TPN, p=023 for SED). (...)
The TPN group consumed more total calories than the SED group (p<. 05).
Weight change during therapy was significantly different from pretreatment in both groups (p<. 01 for TPN, p=023 for SED). (...)
Mots-clés Pascal : Malabsorption intestinale, SIDA, Virose, Infection, Nutrition, Voie parentérale, Voie orale, Traitement diététique, Etude comparative, Analyse coût efficacité, Economie santé, Homme, Appareil digestif pathologie, Intestin pathologie, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : Intestinal malabsorption, AIDS, Viral disease, Infection, Nutrition, Parenteral administration, Oral administration, Diet therapy, Comparative study, Cost efficiency analysis, Health economy, Human, Digestive diseases, Intestinal disease, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0247546
Code Inist : 002B06D01. Création : 11/09/1998.